Scientific References

Neuroinflammation mediates noise-induced synaptic imbalance and tinnitus in rodent models. 
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000307

Wilson BS, Tucci DL, Merson MH, O'Donoghue GM. Global hearing health care: new findings and perspectives. Lancet. 2017;390(10111):2503–15. 
https://pubmed.ncbi.nlm.nih.gov/28705460/

Nondahl DM, Cruickshanks KJ, Huang GH, Klein BE, Klein R, Nieto FJ, et al. Tinnitus and its risk factors in the Beaver Dam offspring study. Int J Audiol. 2011;50(5):313–20. pmid:21309642; PubMed Central PMCID: PMCPMC3073029. 
https://pubmed.ncbi.nlm.nih.gov/21309642/

Yang S, Weiner BD, Zhang LS, Cho SJ, Bao S. Homeostatic plasticity drives tinnitus perception in an animal model. Proc Natl Acad Sci U S A. 2011;108(36):14974–9. Epub 2011/09/08. 1107998108 [pii] pmid:21896771. 
https://pubmed.ncbi.nlm.nih.gov/21896771/

Li S, Choi V, Tzounopoulos T. Pathogenic plasticity of Kv7.2/3 channel activity is essential for the induction of tinnitus. Proc Natl Acad Sci U S A. 2013;110(24):9980–5. pmid:23716673. 
https://pubmed.ncbi.nlm.nih.gov/23716673/

Li S, Kalappa BI, Tzounopoulos T. Noise-induced plasticity of KCNQ2/3 and HCN channels underlies vulnerability and resilience to tinnitus. Elife. 2015;4. pmid:26312501; PubMed Central PMCID. 
https://pubmed.ncbi.nlm.nih.gov/26312501/

Kotak VC, Fujisawa S, Lee FA, Karthikeyan O, Aoki C, Sanes DH. Hearing loss raises excitability in the auditory cortex. J Neurosci. 2005;25(15):3908–18. 
https://pubmed.ncbi.nlm.nih.gov/15829643/

Abbott SD, Hughes LF, Bauer CA, Salvi R, Caspary DM. Detection of glutamate decarboxylase isoforms in rat inferior colliculus following acoustic exposure. Neuroscience. 1999;93(4):1375–81. pmid:10501462. 
https://pubmed.ncbi.nlm.nih.gov/10501462/

Milbrandt JC, Holder TM, Wilson MC, Salvi RJ, Caspary DM. GAD levels and muscimol binding in rat inferior colliculus following acoustic trauma. Hear Res. 2000;147(1–2):251–60. pmid:10962189. 
https://pubmed.ncbi.nlm.nih.gov/10962189/

Browne CJ, Morley JW, Parsons CH. Tracking the expression of excitatory and inhibitory neurotransmission-related proteins and neuroplasticity markers after noise induced hearing loss. PLoS ONE. 2012;7(3):e33272. pmid:22428005. 
https://pubmed.ncbi.nlm.nih.gov/22428005/

Llano DA, Turner J, Caspary DM. Diminished cortical inhibition in an aging mouse model of chronic tinnitus. J Neurosci. 2012;32(46):16141–8. Epub 2012/11/16. 32/46/16141 [pii] pmid:23152598. 
https://pubmed.ncbi.nlm.nih.gov/23152598/

TINNITUS AURIUM IN NORMALLY HEARING PERSONS. 
https://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.656.4670&rep=rep1&type=pdf